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7 results for “drug”

Formulae (7)

t_{1/2} = \frac{0.693}{k_e}

Time for the plasma concentration of a drug to fall to half its initial value.

C_{ss} = \frac{F \times D}{CL \times \tau}

Average plasma drug concentration when intake and elimination are balanced.

V_d = \frac{D}{C_0}

Apparent volume into which a drug distributes — a larger Vd means the drug leaves the bloodstream and enters tissues.

CL = k_e \times V_d

Volume of plasma completely cleared of a drug per unit time.

CrCl = \frac{(140 - \text{age}) \times \text{weight}}{72 \times S_{cr}} \times (0.85 \text{ if female})

Estimates kidney function to guide drug dosing adjustments.

TI = \frac{TD_{50}}{ED_{50}}

Ratio of the dose causing toxicity to the effective dose — a safety measure for drugs.

C(t) = C_0 \times e^{-k_e t}

Drug concentration decreases exponentially — a constant fraction is eliminated per unit time.