Pharmacology & Dosage
Intermediate

Creatinine Clearance (Cockcroft-Gault)

Estimates kidney function to guide drug dosing adjustments.

Formula

CrCl=(140−age)×weight72×Scr×(0.85 if female)CrCl = \frac{(140 - \text{age}) \times \text{weight}}{72 \times S_{cr}} \times (0.85 \text{ if female})

Variables

CrClCreatinine clearance (mL/min)
\text{age}Age in years
\text{weight}Body weight in kg
S_{cr}Serum creatinine (mg/dL)

Example

Age 60, 70 kg, Scr 1.2 → CrCl ≈ 65 mL/min

Did You Know?

The Cockcroft-Gault equation from 1976 is still used daily in hospitals worldwide despite being nearly 50 years old.

pharmacologycreatininekidneyrenal

Share this formula

More in Pharmacology & Dosage

View all

Drug Half-Life

Intermediate

Time for the plasma concentration of a drug to fall to half its initial value.

Steady-State Concentration

Intermediate

Average plasma drug concentration when intake and elimination are balanced.

Loading Dose

Intermediate

Initial higher dose to rapidly achieve the desired plasma concentration.

Maintenance Dose

Intermediate

Recurring dose needed to sustain the steady-state concentration.

Volume of Distribution

Basic

Apparent volume into which a drug distributes — a larger Vd means the drug leaves the bloodstream and enters tissues.

Clearance

Intermediate

Volume of plasma completely cleared of a drug per unit time.