Pharmacology & Dosage
Intermediate

Clearance

Volume of plasma completely cleared of a drug per unit time.

Formula

CL=ke×VdCL = k_e \times V_d

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Variables

CLClearance (L/hr)
k_eElimination rate constant
V_dVolume of distribution

Example

kₑ = 0.1/hr, Vd = 50 L → CL = 5 L/hr

Did You Know?

Renal and hepatic clearance are the two major routes — kidney or liver disease can dramatically slow drug elimination.

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Time for the plasma concentration of a drug to fall to half its initial value.

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Recurring dose needed to sustain the steady-state concentration.

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Apparent volume into which a drug distributes — a larger Vd means the drug leaves the bloodstream and enters tissues.

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