Pharmacology & Dosage
Intermediate

Maintenance Dose

Recurring dose needed to sustain the steady-state concentration.

Formula

MD=Css×CL×τMD = C_{ss} \times CL \times \tau

Variables

MDMaintenance dose
C_{ss}Desired steady-state concentration
CLClearance
\tauDosing interval

Example

Css = 10 mg/L, CL = 6 L/hr, τ = 12 hr → MD = 720 mg

Did You Know?

If the maintenance dose is too low, the drug dips below the therapeutic window between doses — the 'trough' effect.

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