Epidemiology & Public Health
Intermediate

Effective Reproduction Number

Actual average infections per case when part of the population is already immune.

Formula

Re=R0×SR_e = R_0 \times S

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Variables

R_eEffective reproduction number
R_0Basic reproduction number
SFraction of the population still susceptible

Example

R₀ = 3, 40 % immune (S = 0.6) → Rₑ = 1.8

How it works

The effective reproduction number tells you how fast an infection is spreading in a population where some people are no longer available to catch it, usually because they are immune or already infected. It comes from taking the disease’s basic spread potential, R₀, and scaling it by the fraction still susceptible, S, because only those people can be newly infected. If S drops, each case has fewer possible targets, so the average number of secondary cases falls in direct proportion.

When to use it

Use this formula in outbreak monitoring, vaccination planning, and public-health modelling when a disease is circulating in a population that is not fully susceptible. It is especially useful for estimating whether transmission is likely to grow, hold steady, or decline.

Worked example, step by step

Given: R₀ = 4.2 S = 0.35 Step 1: Substitute into the formula Rₑ = R₀ × S Rₑ = 4.2 × 0.35 Step 2: Multiply Rₑ = 1.47 Final answer: The effective reproduction number is 1.47, so each infected person is expected to infect about 1.47 others on average in the current population.

Common mistakes to avoid

  • Using the percentage immune instead of the susceptible fraction S
  • Confusing Rₑ with R₀ and ignoring immunity in the population
  • Assuming Rₑ is fixed even though it changes as susceptibility changes over time

Did You Know?

When Rₑ drops below 1, the outbreak shrinks — this is the goal of every vaccination and lockdown strategy.

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Reviewed & maintained by the FormulaWon editorial teamLast reviewed September 2026